p. 217−228
2228-5415
Vol.14/No.2
p. 229−241
2228-5415
Vol.14/No.2
p. 243−257
2228-5415
Vol.14/No.2
p. 259−272
2228-5415
Vol.14/No.2
p. 273−282
2228-5415
Vol.14/No.2
p. 283−296
2228-5415
Vol.14/No.2
0/05). According to DPPH Evaluation Test for determining the antioxidant capacity of the samples, the highest amount of DPPH was seen in treatment of EN 1000 (p0/05). Also, based on the Restoration Power Test, treatment of EN 1000 had the most meaningful restoration power and in all concentrations of the extract and treatment showed the most meaningful restoration power (p< 0/05) . Treatments with concentration of 1000 ml/l had the maximum total antioxidant capacity and this treatment showed higher total antioxidant capacity compared to BHT treatment and numerically the total antioxidant capacity of all treatments of BHT was allocated to the treatments with concentration of 200 to 500 ml/l of fleawort extract. Peroxide value was used as indicators for the primary oxidation of sunflower oil. Hydroperoxides are the primary products of lipid oxidation. They are odorless and colorless, but are labile species that can undergo both enzymatic and non-enzymatic degradation to produce a complex array of secondary products. Determination of peroxides can be used as oxidation index for the early stages of lipid oxidation During the test time, both normal and encapsulated 1000 treatments had lower peroxide value through incubation time compared to all other treatments and 1000 EN treatment showed the lowest meaningful level of peroxide value (p]]>
p. 297−306
2228-5415
Vol.14/No.2
p. 307−320
2228-5415
Vol.14/No.2
p. 321−334
2228-5415
Vol.14/No.2
p. 335−346
2228-5415
Vol.14/No.2
p. 347−357
2228-5415
Vol.14/No.2
p. 359−369
2228-5415
Vol.14/No.2
p. 371−382
2228-5415
Vol.14/No.2
p. 383−397
2228-5415
Vol.14/No.2
0.8). In this work, the Eudragit was dispersed in ethanol with the curcumin, leading to a homogeneous, yellow transparent solution, and the curcumin and hyaluronan were dispersed in water. After freeze drying and rehydration with water, the vesicle size and polydispersity decreased, leading to the formation of more suitable systems. Liposomes of Eudragit were spherical or oval, multi-lamellar or large uni-lamellar vesicles with some smaller vesicles inside. These liposomes had high entrapment efficiency (>80%) immediately after production without significant decrease after storage. Liposomes of Eudragit S100 had smaller vesicles (287±31 nm) compared to those of Eudragit L100 (407±33 nm) after preparation Moreover, vesicles containing Eudragit S100 showed better stability during storage. Immobilization of liposomes in polymeric network of hyaluronan-Eudragit increased their stability against the mimicking conditions of gastrointestinal tract such as high ionic strength and pH variation. The present study indicated that the combination of P90G, Eudragit S100 and hyaluronan results in the production of innovative delivery systems with suitable dimensions and adequate stability, capable of protecting the curcumin from the pH variation during the stomach to colon transit, and favoring the local accumulation of the drug. Finally, a more detailed research according to ICH and WHO guidelines should be performed in a more advanced development step.]]>
p. 399−410
2228-5415
Vol.14/No.2
p. 411−426
2228-5415
Vol.14/No.2
p. 427−438
2228-5415
Vol.14/No.2
p. 439−449
2228-5415
Vol.14/No.2